Just finished TTS training here at Latus and we are now a dealer for that product. It is the pre-Pro Tuner version of SERT and is by the same people who made SERT. But it has several new features that SERT/SEST does not. How "user friendly" the software is depends on your experiance with SERT. New users to SERT have traditionaly found the learning curve fairly steep.
The TTS does NOT eleminate the need for dyno tuning. In fact a dyno is required for non-closed loop cells, WOT and "learned" cell tuning. An owner can, however with diligence, record "learned" cell VE values and generate new VE tables based on these, in the closed loop active areas. They will not be as accurate as those done on a dyno as they are transitional vs steady state. But this wil not address WOT fuel, timing and open loop functions. Timing could be tuned via data record by looking at knock control but this will not give a complete picture, especially on high compression motors.
Head or compression changes are massive to air flow and the closed loop system may not have the ability to account for these. Other tables may also require adjustments, that are done manually, with these changes.